We next examined the activity of the insulin signaling pathway in 6-mo Pcyt2+/− liver. Consistent with the microarray data, older Pcyt2+/− shows severe impairment in the Irs1/Pi3K/Akt pathway in fasted state (Fig. 3C). Insulin receptor IR was not significantly modified, however, total Irs1 protein was reduced by … Prikaži več Pcyt2+/− mice are similar weights at 2-mo compared to control littermates but progressively gain more weight than controls as they age despite consuming equal … Prikaži več To determine early changes in gene expression caused by Pcyt2 deficiency we assessed the existing microarray data for 2-mo Pcyt2+/− liver (GEO microarray data … Prikaži več Enrichment analysis of RT-PCR arrays for 6-mo Pcyt2+/− liver indicated that insulin signaling, FoxO, mTOR, AMPK and several growth factors that share post … Prikaži več Next, we probed whether PEtn improves hepatic inflammation. Expression of proinflammatory cytokines Infγ, Tnfα and Il-6 were increased by 50%, … Prikaži več SpletAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Clotrimazole: A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Ketoconazole: A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
Bilayer Forming Phospholipids as Targets for Cancer Therapy
SpletMeclizine, a direct inhibitor of PCYT2, is a potential anticancer drug when used in conjunction with the phosphofructokinase (PFKFB3) inhibitor PFK158 [103]. PFK158 inhibits PFKFB3, a key... Splet01. sep. 2012 · Intestinal TAG secretion is elevated in Pcyt2+/− mice. To investigate the extent to which intestinal secretion may contribute to Pcyt2 +/− hypertriglyceridemia, the animals were intravenously injected with the lipase inhibitor P407 as above and then given an intragastric load of labeled olive oil. The secretion of intestinal lipids was monitored … compelling of truth
Nature子刊：肌肉健康依赖于脂质合成 - 生物通
Splet18. maj 2015 · Animals. Pcyt2 +/− mice were generated as described previously (). Pcyt2 +/− mice were cross-bred, and the heterozygous colony was maintained at the University of Guelph, according to procedures approved by the University Animal Care Committee and in agreement with guidelines of the Canadian Council on Animal Care. Pcyt2 +/− and Pcyt2 … SpletPCYT2 inhibition triggers PEtn accumulation during glutamine deprivation • PCYT2 downregulation is associated with poor prognosis for breast cancer patients Summary … Splet22. mar. 2024 · PCYT2 is an enzyme involved in lipid biosynthesis, and its genetic deficiency in zebrafish, mice and humans causes progressive muscle weakness. Importantly, PCYT2 activity declines in ageing ... ebility login.com