Web12 apr. 2024 · Nrf2 is also closely associated with iron metabolism [176,177,178]. Nrf2 coordinates iron homeostasis within LIPs. Especially, Nrf2 promotes ferritin expression. Nrf2-deficient mice showed lower basal FTH1 and FTL levels than wild-type mice [179,180]. The regulation mechanism was uncovered by Pietsch et al. WebIn addition, several different Nrf2 targets are downregulated in patients with FRDA, including ferritin, whose levels are at the lower end of normal in FRDA. 26, 27 There have been previous suggestions that topical Nrf2 application could reverse Nrf2 suppression and improve frataxin levels in FRDA. 7 Nrf2, its downstream pathways, and frataxin ...

Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response

Web21 feb. 2024 · Our data illustrated that ferritinophagy-mediated ferroptosis promoted the EMT inhibition. In addition, activated Nrf2 involved the regulation on both ferroptosis and EMT in response to the alteration in the cellular redox environment. ... NCOA4-mediated ferritin degradation in lysosomes triggered to ferroptosis induction , ... Web1 jan. 2024 · Additionally, the expressions of ferroptosis-related proteins, NF-E2-related factor 2 (Nrf2), ferritin heavy chain 1 (FTH1), heme oxygenase 1 (HO-1), and … marco antonio silvestro la paz

Erianin inhibits oral cancer cell growth, migration, and invasion via ...

Web29 okt. 2024 · NRF2 activation by TBHQ treatment protected against erianin-induced cell death and increased the expression of GPX4, ferritin, xCT and glutaminase. On the … WebFerritin is a 480-kDa intracellular protein that can store up to 4500 atoms of iron (1). The protein consists of 24 subunits of the H and L chain type (2). The ratio of subunits within … WebAntioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. marco antonio soares