Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. … Ver mais The EPAS1 gene encodes one subunit of a transcription factor involved in the induction of genes regulated by oxygen, and which is induced as oxygen concentration falls (hypoxia). The protein contains a Ver mais A high percentage of Tibetans carry an allele of EPAS1 that improves oxygen transport. The beneficial allele is also found in the extinct Denisovan genome, suggesting that it … Ver mais EPAS1 has been shown to interact with aryl hydrocarbon receptor nuclear translocator and ARNTL. Ver mais • EPAS1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … Ver mais Mutations in the EPAS1 gene are related to early-onset neuroendocrine tumors such as paragangliomas, somatostatinomas Ver mais • Brahimi-Horn MC, Pouysségur J (2005). "The hypoxia-inducible factor and tumor progression along the angiogenic pathway". International Review of Cytology. 242: … Ver mais WebGain-of-function mutations in the EPAS1/HIF2A gene have been identified in patients with hereditary erythrocytosis that can be associated with the development of paraganglioma, pheochromocytoma and somatostatinoma. In the present study, we describe a
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Web6 de out. de 2024 · HIF-2α-KO Treg cells have normal suppressive function in vitro. Next, we determined the in vitro suppressive activity of tTreg cells. Cd4 Cre Hif2a f/f tTreg cells … Web23 de mar. de 2024 · To examine the potential role of HIF-2α in renal fibrosis, we generated Hif2a conditional heterozygous knockout mice (Hif2a CKO) with Hif2a deleted in their interstitial cells (confirmed by ... curfew ocga
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Web21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, Multiple, Ollier Type.Among its related pathways are Signaling by PTK6 and Regulation of activated PAK-2p34 by proteasome mediated degradation.Gene … WebHIF2 alpha antibody detects HIF2 alpha protein by western blot analysis. Non-transfected (-) and HIF2A-transfected (+, including Myc-DDK-tag) 293T whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with HIF2 alpha antibody (GTX30114) diluted by 1:1000. Web3 de jul. de 2003 · Function. Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence … curfew notice